منابع مشابه
A Decade of Riboswitches
Riboswitches were discovered in 2002 in bacteria as RNA-based intracellular sensors of vitamin derivatives. During the last decade, naturally occurring RNA sensor elements have been found to bind a range of small metabolites and ions and to exert regulatory control of transcription, translation, splicing, and RNA stability. Extensive biochemical, structural, and genetic studies have established...
متن کاملFlipping Riboswitches
Riboswitches are common cis-acting regulatory elements in bacteria. They are made of nascent RNA that changes its conformation in response to direct binding of cognate metabolites. The publication of five high-resolution crystal structures provides a comprehensive view of how riboswitches sense their ligands and points to new challenges in this emerging field.
متن کاملBacterial riboswitches
This wikipedia entry provides an extensive description of natural and engineered riboswitches. Most known riboswitches have been found in bacteria. This webpage provides a link to an electronic thesis file describing a riboswitch that responds to the herbicide atrazine. This web article discusses synthetic riboswitches. These are tools that researchers can use to control bacterial metabolism. T...
متن کاملRiboswitches: structures and mechanisms.
A critical feature of the hypothesized RNA world would have been the ability to control chemical processes in response to environmental cues. Riboswitches present themselves as viable candidates for a sophisticated mechanism of regulatory control in RNA-based life. These regulatory elements in the modern world are most commonly found in the 5'-untranslated regions of bacterial mRNAs, directly i...
متن کاملDynamics of riboswitches: Molecular simulations.
Riboswitch RNAs play key roles in bacterial metabolism and represent a promising new class of antibiotic targets for treatment of infectious disease. While many studies of riboswitches have been performed, the exact mechanism of riboswitch operation is still not fully understood at the atomistic level of detail. Molecular dynamics simulations are useful for interpreting existing experimental da...
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ژورنال
عنوان ژورنال: Cell
سال: 2013
ISSN: 0092-8674
DOI: 10.1016/j.cell.2012.12.024